Novinky

Studies That Show Cannabis Grows Brain Cells
 
 

http://www.jci.org/articles/view/25509

Cannabis (marijuana, hashish, or cannabinoids) has been used for medical and recreational purposes for many centuries and is likely the only medicine or illicit drug that has constantly evoked tremendous interest or controversy within both the public domain and medical research.
Cannabinoids appear to be able to modulate pain, nausea, vomiting, epilepsy, ischemic stroke, cerebral trauma, multiple sclerosis, tumors, and other disorders in humans and/or animals.
However, marijuana has been the most commonly used illicit drug in developed countries, producing acute memory impairment and dependence/withdrawal symptoms in chronic users and animal models.
Cannabis acts on 2 types of cannabinoid receptors, the CB1 and CB2 receptors, which are distributed mainly in the brain and immune system, respectively.
In the brain, CB1 receptors are also targeted by endogenous cannabinoids (i.e., endocannabinoids) such as anandamide (AEA), 2-arachidonylglycerol, and arachidonylethanolamide.

 

The recent discovery that the hippocampus is able to generate new neurons (i.e., neurogenesis) throughout the lifespan of mammals, including humans, has changed the way we think about the mechanisms of psychiatric disorders and drug addiction.

 

The subgranular zone of the dentate gyrus (SGZ) in the adult brain contains neural stem/progenitor cells (NS/PCs) capable of producing thousands of new granule cells per day.
We, and others, have shown that these newborn hippocampal neurons are functionally integrated into the existing neuroanatomical circuitry and are positively correlated with hippocampus-dependent learning and memory processes and the developmental mechanisms of stress and mood disorders. …

 

Chronic administration of the major drugs of abuse including opiates, alcohol, nicotine, and cocaine has been reported to suppress hippocampal neurogenesis in adult rats, suggesting a potential role of hippocampal neurogenesis in the initiation, maintenance, and treatment of drug addiction.
The recent finding of prominently decreased hippocampal neurogenesis in CB1-knockout mice suggests that CB1 receptor activation by endogenous, plant-derived, or synthetic cannabinoids may promote hippocampal neurogenesis.

 

However, endogenous cannabinoids have been reported to inhibit adult hippocampal neurogenesis.
Nevertheless, it is possible that exo- and endocannabinoids could differentially regulate hippocampal neurogenesis, as exo- and endocannabinoids act as full or partial agonists on CB1 receptors, respectively.

 

The goal of the present study was to test the hypothesis that the potent synthetic cannabinoid HU210 is able to promote hippocampal neurogenesis, leading to the anxiolytic and antidepressant effects of cannabinoids.
We demonstrate here that both HU210 and the endocannabinoid AEA promote proliferation of embryonic hippocampal NS/PCs without significant effects on their differentiation, resulting in more newborn neurons.
The effects of HU210 on adult hippocampal neurogenesis were quantified in freely moving rats and were correlated with behavioral testing.

 

We show that 1 month after chronic HU210 treatment, rats display increased newborn neurons in the hippocampal dentate gyrus and significantly reduced measures of anxiety- and depression-like behavior.
Thus, cannabinoids appear to be the only illicit drug whose capacity to produce increased hippocampal newborn neurons is positively correlated with its anxiolytic- and antidepressant-like effects.

http://www.jci.org/articles/view/25509

CBD and anxiety, depression

What You Need to Know About CBD Oil for Anxiety

 
 
CBD Oil for Anxiety
3.4
1162
 

Over the last decade, an increasing number of people have started using CBD oil for anxiety and stress relief.

With the passage of the 2018 farm bill in the US and the full legalization of industrial hemp, CBD is set to become a nation-wide home remedy for anxiety, depression, and many other debilitating conditions.

 

Even though research is still in the early stages in establishing whether hemp oil, cannabis oil or other marijuana products represent a viable treatment for anxiety, depression, and stress, people who’ve used them claim an overall decrease in symptoms.

Here we try to clear up some common misconceptions about CBD, where to find it, how to use it, and how it can help you with anxiety.

To understand the effects and health benefits of CBD, cannabis oil, hemp oil, and medical marijuana, we will look at how these supplements affect our brain and consequently our body.

What is CBD?

Although the cannabis plant contains tens of active ingredients, only two have caught the attention of researchers – THC and CBD.

CBD stands for cannabidiol, the central cannabinoid found in cannabis and industrial hemp. Decades of research have concluded that, in a moderate dose, CBD can have numerous health benefits.

 

Unlike THC (tetrahydrocannabinol), cannabidiol doesn’t have any psychoactive effects on the brain which means you can’t get ‘high’ even if you get the dosage wrong.

By having a direct impact on CB1 receptors, CBD can affect your serotonin levels – the neurotransmitter that plays a huge role in mood disorders. [3] And that’s why using CBD oil for anxiety, stress, and depression might prove to be a viable option.

Whether it comes in the form of capsules, hemp oil, vape oil, pure CBD oil, CBD gummies, or other edibles, cannabidiol might just be the next breakthrough in mental health.

CBD Oil Effects

If you’re dealing with an emotional problem like anxiety and find it extremely difficult to tolerate the unpleasant side effects of psychiatric medication, hemp oil or any other cannabis product that contains CBD may be a good alternative.

As one 2010 paper published in the Journal of Psychopharmacology suggests, both human and animal studies indicate that cannabidiol, one of the primary compounds found in cannabis and marijuana, can serve as a viable treatment for anxiety. [4]

 

In fact, some clinical trials have revealed that CBD oil is effective for a wide range of conditions, from chronic pain, multiple sclerosis, and Alzheimer’s disease to depression, stress, and anxiety. Furthermore, it can lower blood pressure and act as a natural anti-inflammatory supplement.

But CBD oil can be of great use even for those of us dealing with specific forms of anxiety. For example, a 2011 study published in Neuropsychopharmacology, revealed that cannabidiol could reduce social anxiety – one of the most common types of anxiety disorders. [5]

In a nutshell, cannabidiol seems to have important health benefits which make it a supplement worth taking into consideration.

Does CBD Get You High?

Many of you are probably worried that using CBD oil for anxiety will get you ‘high.’ Fortunately, it’s impossible to get ‘high’ off CBD, since it doesn’t have any psychoactive effects on the brain.

While cannabidiol does interfere with all sorts of neurotransmitter receptors, the ‘high’ is always the result of THC. In short, no THC, no high.

And if that isn’t enough to convince you, bear in mind that CBD oil, hemp oil, and other cannabidiol-based products are available in most countries around the world – even countries where both medical and recreational marijuana is illegal.

Is CBD Addictive?

The most straightforward answer to this question is no. The use of cannabidiol, unlike the use of weed or marijuana products, isn’t addictive.

As one report issued by the World Health Organization in 2018 clearly states, at present no public health problems (e.g., driving under the influence of drugs cases, comorbidities) have been associated with the use of pure CBD. [6]

 

Even if you take a higher dose, there’s no way you could ever get addicted to cannabidiol.

Is CBD Safe?

Since cannabidiol proves to be effective in treating a wide array of medical and psychological conditions, we can reasonably assume CBD-based products are safe. In fact, millions of people around the world are using this supplement regularly, without experiencing any medical complications.

Furthermore, human and animal studies have revealed that cannabidiol is a safe compound that can prevent colitis in mice [7] and also act as a chemopreventive supplement for colon cancer. [8]

Overall, experts can agree that using CBD oil for anxiety is a perfectly safe and surprisingly effective alternative to traditional treatments.

How Can CBD Oil Help With Anxiety?

Many anxiety sufferers use hemp oil, CBD oil, and other similar supplements to sleep better and deal with the constant stream of worry-filled thoughts associated with this emotional problem.

One case report published by The Permanente Journal in 2016 revealed that cannabidiol might be a safe treatment for the anxiety and insomnia associated with post-traumatic stress disorder. [10]

 

CBD Oil for Anxiety

But that’s not all. A 2013 study conducted on mice revealed that repeated administration of CBD could trigger hippocampal neurogenesis (the regeneration of neurons in the hippocampus). [11]

For those of you who don’t know, the hippocampus is a brain region responsible for cognition and memory. In the case of depression or anxiety sufferers, this brain area tends to be smaller, which may explain some of the irrational thinking patterns specific to these conditions.

Overall, it seems cannabidiol is not just a placebo, but a compound that can directly impact the functioning of various brain areas and neurotransmitter receptors.

What The Research Says

As a rational and decently cautious person, you may be wondering what researchers have to say about the use of CBD oil for anxiety.

Not only that cannabidiol can lower anxiety, but it also helps reduce the symptoms associated with a wide range of psychological conditions and brain disorders.

The studies I mentioned above indicate, CBD may prove to be an effective treatment for:

  • Post-traumatic stress disorder
  • Generalized anxiety disorder
  • Social anxiety
  • Depression
  • Insomnia
  • Stress

Neurochemistry and CBD

Did you know that the human body has a built-in system designed explicitly for processing cannabinoids?

It’s called ‘the endocannabinoid system’ and it plays a major role in homeostasis – the body’s ability to maintain a healthy inner balance. This means CBD oil and other derived supplements can regulate sleep, appetite, mood, and consequently the level of anxiety we might be experiencing at a given moment.

But what’s truly fascinating is that this compound can have a real impact on the brain receptors involved in the body’s response to anxiety.

For example, cannabidiol works just like SSRIs (selective serotonin reuptake inhibitors) – a category of psychiatric drugs specifically designed for anxiety and depression. By bringing your serotonin to normal levels, CBD-based supplements can significantly reduce the symptoms of anxiety.

CBD Oil Dosage for Anxiety

While the FDA does approve CBD as a supplement for a wide range of medical and psychological conditions, it’s also firmly against companies that market cannabidiol as a ‘100% guaranteed’ cure against severe medical conditions.

But even though CBD oil for anxiety is an FDA-approved treatment, experts still find it difficult to determine the right dosage. You need to keep in mind that finding the right dose depends on a wide array of factors, from weight and age to the intensity of the symptoms.

Fortunately, since cannabidiol is a safe and non-psychoactive compound, you don’t have to worry about taking a dangerously high dose. The worst thing that can happen is feeling a bit nauseous or dizzy, symptoms which indicate you need to lower the dose.

On top of that, you can determine the ideal dose for you by consulting a medical professional or asking the manufacturer.

Bottom Line: Can CBD Help Treat Anxiety?

All in all, products derived from marijuana, cannabis, or hemp plant (ex. CBD oil, hemp oil, cannabis oil, and many more) can be an effective treatment for mood disorders like anxiety and depression.

In fact, a 2007 study published by Chemistry & Biodiversity points out, the plethora of positive pharmacological effects observed with CBD make this compound a highly attractive therapeutic entity. [12]

But just to be 100% safe, make sure to consult a physician before you decide to use CBD oil for anxiety or any other condition.

Resources

[1] n.a., “Depression and Other Common Mental Disorders: Global Health Estimates,” World Health Organization, Geneva, 2017.

 

[2] R. E. Musty, “Cannabinoids and anxiety,” in Cannabinoids as Therapeutics, Basel, Birkhäuser, 2005, pp. 141-147.

 

[3] D. R. Wilson, “Using CBD Oil for Anxiety: Does It Work?,” Healthline Media, 10 April 2017. [Online]. Available: https://www.healthline.com/health/cbd-for-anxiety.

 

[4] J. A. S. Crippa, G. N. Deremusson, T. B. Ferrari and a. others, “Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report,” Journal of Psychopharmacology, vol. 25, no. 1, 2010.

 

[5] M. M. Bergamaschi, R. H. Costa Queiroz, M. H. Nisihara Chagas and a. others, “Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients,” Neuropsychopharmacology , vol. 36, p. 1219–1226, 2011.

 

[6] n.a., “CANNABIDIOL (CBD) Critical Review Report,” World Health Organization, Geneva, 2018.

 

[7] F. Borrelli, G. Aviello, B. Romano, P. Orlando, R. Capasso, F. Maiello and a. others, “Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis,” Journal of Molecular Medicine, vol. 87, p. 1111, 2009.

 

[8] G. Aviello, B. Romano, F. Borrelli, R. Capasso, L. Gallo, F. Piscitelli, V. Di Marzo and A. A. Izzo, “Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer,” Journal of Molecular Medicine, vol. 90, no. 8, p. 925–934, 2012.

 

[9] C. Wong, “Can CBD Oil Treat Anxiety?,” Verywell, 23 October 2018. [Online]. Available: https://www.verywellhealth.com/cbd-oil-for-anxiety-4176279.

 

[10] S. Shannon and J. Opila-Lehman, “Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report,” The Permanente Journal, vol. 20, no. 4, pp. 108-111, 2016.

 

[11] A. Campos, Z. Ortega, J. Palazuelos, M. Fogaca, D. Aguiar, J. Diaz-Alonso, S. Ortega-Gutierrez and a. others, “The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.,” International Journal of Neuropsychopharmacology, vol. 16, no. 6, pp. 1407-1419, 2013.

 

[12] R. Mechoulam, M. Peters, Murillo-Rodriguez, Eric and L. O. Hanuš, “Cannabidiol – Recent Advances,” Chemistry & Biodiversity, vol. 4, no. 8, pp. 1678-1692, 2007.

 

 
 
 
Léčba nemoci Motýlích křídel CBD

IACM: ÚSPĚŠNÁ LÉČBA NEMOCI MOTÝLÍCH KŘÍDEL POMOCÍ EXTRAKTU BOHATÉHO NA CBD

Američtí lékaři z Dermatologického oddělení Univerzity Západní Virginie a Lékařské fakulty Stanfordovy univerzity publikovali v červenci výsledky výzkumu, který sledoval konopnou léčbu tří malých pacientů (ve věku šest měsíců, tři a deset let) s vzácným vrozeným onemocněním epidermolysis bullosa (EB)

 
 
IACM: Úspěšná léčba nemoci motýlích křídel pomocí extraktu bohatého na CBD

Choroba známá též jako nemoc motýlích křídel se projevuje zejména na kůži, kde se spontánně nebo po sebemenším kontaktu objevují puchýře, může ale zasáhnout i ústní dutinu, dýchací soustavu či urogenitální trakt. Autoři v abstraktu konstatují, že konvenční léčba je „obtížná z důvodu citlivosti a křehkosti kůže a je provázena svěděním, bolestí, omezenou pohyblivostí a častým výskytem infekcí.“ Podle nich se jako nadějný prostředek na léčbu EB jeví kanabidiol, u kterého byly prokázány protizánětlivé a analgetické účinky. „V rámci observační studie jsme sledovali průběh a výsledky topikální samoléčby EB pomocí CBD u tří pacientů. U všech tří bylo pozorováno rychlejší hojení ran, zmírnění bolesti a menší tvorba puchýřů.“ U jednoho pacienta se dokonce podařilo zcela vysadit orálně užívané opioidní léky proti bolesti.

Pacienti užívali CBD extrakt v oleji, v mastích a ve spreji, přičemž všechny způsoby aplikace měly podle rodičů pozitivní účinek, nicméně výzkumný tým v závěru práce, která byla zveřejněna v lékařském žurnálu Pediatric Dermatology, upozorňuje, že „tyto výsledky jsou sice nadějné, přesto je nutné provést randomizované a dvojitě zaslepené klinické studie pro vědecké potvrzení námi sledovaných účinků kanabidiolu při léčbě EB.“ 

Zdroj: www.ncbi.nlm.nih.gov

 

CBD: studie: hokejisté

Konopí jako lék. Trpící hokejisté z NHL absolvují unikátní studii

Konopí, ilustrační snímek | foto: Profimedia.cz

 
 
Sto bývalých hokejistů NHL, kteří trpí následky opakovaných otřesů mozků, bude součástí roční klinické studie zkoumající vliv kanabidiolu na jejich stavy. O této látce, jíž se zkráceně říká CBD, se už delší dobu mluví jako o naději na mnoho zdravotních a psychických obtíží. Jak pomáhá? A v čem je jiná od THC, kvůli které se marihuana kouří?
 

Tak zaprvé: CBD není návykový a nepůsobí psychotropně. To ho ostatně odlišuje také od opiátů, které bývalí hokejisté trpící postkomočním syndromem užívají.

„Očekávání jsou velká,“ říká Andrew Alberts, bývalý obránce Vancouveru, který byl nucen ukončit kariéru v roce 2013. „Myslím, že nejsem jediný, který se na konopí docela spoléhá. Všichni jsme zvědaví, jestli nám může pomoct.“

 

Hokejisté, kteří trpí postkomočním sydromem, mnohdy skutečně prožívají muka. Nejznámějším příkladem za poslední dobu je někdejší hvězda Detroitu Johan Franzén, jenž je kvůli opakovaným úderům do hlavy vyřazený z běžného života.

Zpočátku ho trápily „jen“ bolesti hlavy, poruchy soustředění, závratě a únava. Posléze se k problémům přidala nespavost, podrážděnost a pocit frustrace. Nakonec vše dospělo do úzkostných stavů a těžkých depresí.

Prokázané účinky CBD

 

  • zklidňuje a zlepšuje spánek
  • zpomaluje buněčné stárnutí
  • harmonizuje přirozené procesy
  • podporuje obranyschopnost 
  • má antidepresivní účinky
  • zmírňuje bolesti
  • působí na neurodegenerativní poruchy (Alzheimer, Parkinson, roztroušená skleroza, mrtvice)
  • podporuje chuť k jídlu
  • vhodný na kožní problémy
  • proti křečím (podpůrná léčba epilepsie)

 

Léčba pomocí CBD by mohla zmírnit podobné soužení a výrazně tím bývalým hráčům zkvalitnit život.

Chystaná studie je důležitá z jednoho prostého důvodu: dosud se vědecky nezkoumaly účinky konopí na postkomoční syndrom u lidí. „Máme dost indicií, že by to mohlo přinést úlevu díky zklidňujícím účinkům pro lidi s traumatickým poraněním mozku. Dobrým předpokladem pro toto tvrzení je fakt, že CBD potlačuje stres, napětí, impulzivitu, podrážděnost a zlepšuje kognitivní funkce,“ říká Zach Walshe, profesor psychologie na Univerzitě Britská Kolumbie.

Lékař Mark Ware, jeden z členů týmu, který výzkum povede, dodává: „Dosavadní výzkumy na zvířatech nám dávají velkou naději. Teď vše musíme prověřit na lidech. Spoustu lidí vypráví o tom, jak jim CBD pomáhá, tak k tomu chceme nasbírat doložitelná data.“

Jak bude výzkum probíhat? V pravidelných intervalech se budou provádět magnetické rezonance a jiné skenování mozků hráčů. Vědci v něm a v nervových vláknech budou sledovat pohyb krve.

Kromě toho budou hráči pravidelně dotazovaní na fyzické a duševní zdraví, užívání opiátů a dalších léků, absolvují krevní testy, speciálními přístroji se bude zkoumat jejich řeč, psací návyky, paměť a emoční stav.

Riley Cote (vlevo) utrpěl během hokejové kariéry několik otřesů mozků. Do hlavy...

Riley Cote (vlevo) utrpěl během kariéry několik otřesů mozků. Do hlavy dostával rány i při bitkách

 

Bývalí hokejisté budou také každý den číst nahlas různé příběhy, zatímco software bude zkoumat a analyzovat změny v řeči. Jejich paměť bude testována otázkami na příběhy staré několik týdnů.

Dvacet hráčů ze stovky bude dostávat placebo, zbytek skutečný kanabidiol. Zajímavostí je, že se studie zúčastní hokejisté z různých období NHL, tedy i borci, kteří hráli ještě bez helmy. Výzkum bude trvat rok a bude-li úspěšný, bude následovat další, mnohem rozsáhlejší.

Naději vzbuzují osobní zkušenosti dvojice bývalých borců, kteří působili ve Philadelphii a mají problémy s následky opakovaných otřesů mozku. Jedním z nich je bývalý bitkař Riley Cote, jenž nadšeně vypráví o tom, jak mu CBD ulevuje od bolesti, úzkostí a depresí. Což potvrzuje i Dan Carcillo. Toho v roce 2015 navíc zasáhla smrt 35letého kamaráda Stevea Montadora, která se přičítá právě postkomočnímu syndromu.

 
 
 
CBD: coolest food and drink ingredient
 

How CBD has become the USA's coolest food and drink ingredient

Meirav Devash, CNN • Published 8th October 2018
 
  • kokus zen bowl cbd
     
  • plant medicine miami
     
  • Gron drinking chocolate CBD
     
  • coalition brewing CBD beer
     
  • James Nomad Hotel CBD Menu
     
  • Vege Nation CBD Whiskey Tea
     
  • ZenBarn CBD Burger
     
  • Adriaen Block CBD Negroni
     
  • broomwagon lexington kentucky
     
 
1/9
(CNN) — The latest "it" ingredient to hit menus is CBD, short for cannabidiol, one of over 60 cannabinoids found in the cannabis sativa plant (more commonly known as marijuana).
Unlike THC, the most well-known cannabinoid, CBD has no psychoactive effects. So, while it won't get you high, its reported therapeutic properties have driven CBD sales and popularity in the wellness industry.
While researchers are still trying to determine CBD's effects, some studies suggest it can help treat inflammation, pain, anxiety and seizures.
The controversy around this superfood stems from inconsistent cannabis regulation at the federal and state level. Despite growing legalization, the DEA still considers cannabis -- including CBD, unless sourced from industrial hemp -- an illegal drug.
To date, the FDA hasn't approved any CBD products apart from an epilepsy drug called Epidiolex. State laws vary and are changing all the time.
Take California, a state with legalized recreational cannabis and a famously vibrant cannabis cuisine scene: Just this summer, the California Department of Public Health stopped the sale of CBD additives in food and drink until it receives full FDA approval.
This left restaurants such as Gracias Madre and Superba Food + Bread scrambling to change their menus to accommodate the rule.
With the Golden State out of the culinary cannabis spotlight at the moment, it's time to highlight some other less celebrated locations where you can find CBD-infused treats out in the wild.
From a sleek, wellness compound in Miami to a Portland dive bar known for late-night hot dogs, here are the coolest spots to find CBD on the menu (for now).

Adriaen Block, Queens, NY

Adriaen Block CBD Negroni
 
 
Adriaen Block's CBD Negroni.
Lily Brown/Adriaen Block
This newly opened Queens cocktail bar and restaurant is a CBD mecca, showcasing the ingredient front and center.
For the uninitiated, the menu offers a word of advice: "CBD will not get you high, but you may experience a calming sensation."
The infused drinks include the Stoney Negroni, Rolled Fashioned, and the Bakin' & Eggs, which is made with Pineau des Charente, Lillet Blanc, blood orange bitters, egg white, and garnished with crisped bacon.
Teetotalers can get in on the action too, thanks to an equally thoughtful selection of CBD mocktails made with Seedlip, a swanky, non-alcoholic distilled spirit. Not thirsty? Also on offer are entrees with a side of AB CBD sauce or a pillowy blob of CBD-infused whipped cream to top off dessert.
Adriaen Block, 19-33 Ditmars Blvd, Astoria, NY 11105, +1 (718) 686-1391

Broomwagon, Lexington, KY

A community mecca for bike culture, this bicycle shop is also a beer garden and café serving up locally-sourced coffee, creative comfort food and ice-cold crafts and drafts.
Customers bringing in their bike for repairs can enjoy a snack by the mechanic's work area while they wait, or check out the latest wheels and accessories. (New pannier bag, anyone?)
They'll add a dose of CBD to any beverage for $2, or you can order a specialty drink like the Sage Advice Latte, with maple and sage-infused syrup, espresso, steamed milk and CBD.
Broomwagon Coffee + Bikes, 800 N. Limestone St., Lexington, KY 40505, +1 (859) 554-6938

Koku, Brooklyn, NY

kokus zen bowl cbd
 
 
This Kokus Zen bowl delivers on its name.
Courtesy Kokus
Think of the Zen Bowl as an ice cream sundae for the Goop set -- dairy-free, probiotic-enriched coconut soft-serve heaped with colorful superfood toppings like antioxidant blueberries, nutritious black sesame granola and CBD cacao magic shell.
Available April through October at Brooklyn's Smorgasburg on Saturdays in Williamsburg and Sundays in Prospect Park, it's allergy-free and utterly Instagrammable.
You can also find the frozen treat at sporadic pop-ups (check their website for upcoming events), but stay tuned: A brick and mortar location is in the works for next year.
Koku, multiple locations

Donnie Vegas, Portland, OR

The coolest downtown Las Vegas dive bar is actually located in Northeast Portland, serving cocktails on tap and cheap, creative hot dogs like the Seoul Dog (kimchi, sambal aioli, scallion) and Tijuana Dog (cream cheese, pico de gallo, jalepeno) until 2:30 am.
They offer Jell-O shots and wine in a can, and a slushee with a hemp-derived twist -- the Prickly Pear CBD Margaweeda, made with fresh lime juice, triple sec, silver tequila and prickly pear puree.
Donnie Vegas, 1203 NE Alberta St, Portland, OR 97211, +1 (503) 477-7244

Green Goddess Cafe, Stowe, VT

This homey café, a neighborhood go-to for fresh-pressed juices and tasty breakfast scrambles, was one the first in Vermont to put the wellness ingredient on the menu after "we experienced the benefits of CBD firsthand with our son, who has autism and a tumor disorder," owner Athena Scheidet says.
One of their most popular specialty drinks is the Jamaican Me Shake, a CBD smoothie with tropical fruit, spinach, avocado, organic apple juice and whipped cream.
Green Goddess Cafe, 618 S Main St, Stowe, VT 05672, +1 (802) 253-5255

The James New York NoMad, New York City

James Nomad Hotel CBD Menu
 
 
The James NoMad brings CBD to R-n-R.
Courtesy The James Nomad
Travelers who want a break from Manhattan's hectic pace don't even need to leave their boutique hotel room for the latest way to unwind -- CBD-infused room service from notable cannabis chef Annabel Drummer.
The in-room dining menu includes spicy meatballs, gorgonzola salad with walnuts and pear, and house tater tots. Or, you can pick a prepackaged CBD-infused treat like Chef For Higher Gummies, Grön Chocolate bars, and even Bark Avenue dog treats for stressed pets.
The James NoMad, 22 E 29th St, New York, NY 10016, +1 (212) 532-4100

VegeNation, Las Vegas

VegeNation CBD Whiskey Tea
 
 
Stay hydrated in Vegas with this whiskey CBD tea.
Courtesy Vege Nation
Downtown Las Vegas's Fremont East area has become an artsy hub for plant-based eats and health-conscious cocktails -- the antithesis of the Strip's bottle service and Champagne-shower decadence.
Affordable global street food at VegeNation is locally grown and plant-based, and even the cocktails have a positive spin -- particularly The Changemaker, a refreshing, infused whiskey tea made with local distilled liquor and tea from Bloomin' Desert Herb Farm, a brew of rosemary, ginger, holy basil, red clover, nettle, peppermint, clove and raw CBD oil in purified water.
VegeNation, 616 Carson Ave #120, Las Vegas, NV 89101, +1 (702) 366-8515

Plant Miami, Miami

plant medicine miami
 
 
The secret ingredient in Plant Miami's drink isn't so secret.
Courtesy Plant Miami
Miami isn't all neon lights, and pumping basslines. When the South Beach scene feels like it's all too much, find your Zen at Sacred Space Miami.
The minimalist oasis in once-gritty Wynwood features a lush meditation garden, yoga and wellness classes, and Plant Miami, an organic, vegan farm-to-table restaurant.
The tropical Plant Medicine cocktail -- with fresh pineapple, house coconut milk, dark rum, and a dose of CBD oil -- is the perfect blend of Miami vibes and mindfulness.
Plant Miami, 105 Northeast 24th St, Miami, FL, 33137, +1 786 621 5006

River and Woods, Boulder

The comfort food at this historic cottage includes community-sourced dishes like Aunt Penny's Mac & Cheese with mushrooms and onion-potato crunch and John's Gnocchi Verde with spinach, Reggiano cream, and lemon zest.
There are family-friendly picnic tables in back, as well as an adult-centric Airstream that serves as an outdoor bar, where you can add a dose of CBD to cocktails like the Sloe Descent, with Luxardo amaretto, Spirit Works sloe gin, orange and pomegranate juice.
(They're in the process of formulating a dedicated CBD-infused wellness cocktail, too.)
River and Woods, 2328 Pearl St, Boulder, CO 80302, (303) 993-6301

Coalition Brewing, Portland, OR

coalition brewing CBD beer
 
 
IPA + CBD = Coalition Brewing's Two Flowers brew.
Courtesy Coalition Brewing
 
This brewery changed the game with Oregon's first commercially produced CBD-infused beer, Two Flowers IPA, highlighting the kinship between cannabis and hops with an aromatic, grassy flavor.
The beer has become so popular that you can find it all over town at establishments like EastBurn Public House and Dot's Café, though it's worth a visit to the tasting room's new patio where you can enjoy it in its original birthplace.
Coalition Brewing, 2705 SE Ankeny St, Portland, OR 97214, +1 (503) 894-8080

Zenbarn, Waterbury, VT 05676

ZenBarn CBD Burger
 
 
Yes, even your burger can help you chill.
Courtesy ZenBarn
You haven't reached peak Vermont until you've visited this rustic barn-turned-restaurant's periodic "Hemp and Hops" dinners, where five-course meals are infused with CBD and paired with local craft beers.
It's a community-focused space, with a yoga studio upstairs and live music at night. (Be prepared to hear Grateful Dead covers.)
The daily menu offers CBD-spiked aioli for their burgers, including the vegetarian Zen Burger, a local black bean patty piled with cheddar, chipotle crema, avocado, lettuce, and crispy onion.
There's also CBD honey vinaigrette for salad, a CBD brownie sundae with house-made CBD caramel, and clever CBD cocktails with names like Gin and Chronic, Le Verde and Up in Smoke.
Zenbarn, 179 Guptil Rd, Waterbury Center, VT 05677, +1 (802) 244-8134

Grön Cafe Portland, OR

Gron drinking chocolate CBD
 
 
 

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